منابع مشابه
Drug research: dead end or new horizon?
Drug research: dead end or new horizon? Industrial drug research is facing a crisis. Higher investments are necessary for the discovery of fewer drugs, and the return on investment shrinks.1 2 Regulatory constraints3 and financial pressures4 have been blamed for slowing the development of new drugs at a time when truly new discoveries have become rare events. Among the new drugs established in ...
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Many philosophers take it for granted that epiphenomenalism is obviously a dead end for an understanding of the human mind and its relation to the physical world and nothing but a counterintuitive theory of last resort. Others, by contrast, think that epiphenomenalism might be the way out of some of the severest problems discussed in the philosophy of mind during the past decades. Traditionally...
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It was suggested more than 30 yrs ago that inhibition of the clotting cascade by natural anticoagulants could decrease the high mortality observed in patients suffering from severe sepsis and septic shock. Unfortunately, this therapeutic "paradigm" has led to a dead end, illustrated by the failure of all randomized trials and the recent withdrawal of recombinant activated protein C. Should we n...
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Recent techniques for inferring business relationships between ASs [1, 2] have yielded maps that have extremely few invalid BGP paths in the terminology of Gao [3]. However, some relationships inferred by these newer algorithms are incorrect, leading to the deduction of unrealistic AS hierarchies. We investigate this problem and discover what causes it. Having obtained such insight, we generali...
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ژورنال
عنوان ژورنال: Nature
سال: 1978
ISSN: 0028-0836,1476-4687
DOI: 10.1038/271009a0